The Effect of Combining Resistance Training and Endothelial Progenitor Cell Injection on the Expression of Angiogenic Factors In Diabetic Male Rats Induced By Stz

Background: Angiogenesis disorders are known mechanisms of diabetes. With the aim of reducing angiogenesis disorders, resistance training and its combination with endothelial progenitor cell injection are new strategies. Therefore, the present study was performed to determine the effect of resistance training with endothelial progenitor cell injection on the expression of angiogenic factors in the skeletal muscle of diabetic rats. Methods: In this study, 30 rats were randomly divided into 5 groups: healthy, control (D) diabetic, trained diabetic (DR), endothelial progenitor cell (DI) diabetic, trained endothelial progenitor cell (DRI) diabetic) Were divided. Ang1 and Tie2 protein expression changes were measured by Western blotting. Data were analyzed using two-factor analysis of variance with SPSS software version 19 at a significance level of 5% α≤. Results: In this study, 6 weeks of resistance training led to a significant increase in Ang1 and Tie2 proteins. But injection of endothelial progenitor cells was significant only on the amount of Tie2 protein. The interactive effect of resistance training and endothelial progenitor cell injection was significant only on the amount of Tie 2 protein. In other words, the combination of resistance training and endothelial progenitor cell injection was superior to Tie2 protein expression than training or injection alone. Conclusion: It can be said that resistance training improves angiogenesis in diabetics. Combining resistance training with endothelial progenitor cell injections could possibly stimulate angiogenesis in skeletal muscle and be a new strategy in the treatment of diabetic disorders.